fido - Bayesian Multinomial Logistic Normal Regression

Provides methods for fitting and inspection of Bayesian Multinomial Logistic Normal Models using MAP estimation and Laplace Approximation as developed in Silverman et. Al. (2022) <https://www.jmlr.org/papers/v23/19-882.html>. Key functionality is implemented in C++ for scalability. 'fido' replaces the previous package 'stray'.

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cppopenmp

8.10 score 20 stars 168 scripts 295 downloads

philr - Phylogenetic partitioning based ILR transform for metagenomics data

PhILR is short for Phylogenetic Isometric Log-Ratio Transform. This package provides functions for the analysis of compositional data (e.g., data representing proportions of different variables/parts). Specifically this package allows analysis of compositional data where the parts can be related through a phylogenetic tree (as is common in microbiota survey data) and makes available the Isometric Log Ratio transform built from the phylogenetic tree and utilizing a weighted reference measure.

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immunooncologysequencingmicrobiomemetagenomicssoftware

7.96 score 19 stars 132 scripts 486 downloads

RcppHungarian - Solves Minimum Cost Bipartite Matching Problems

Header library and R functions to solve minimum cost bipartite matching problem using Huhn-Munkres algorithm (Hungarian algorithm; <https://en.wikipedia.org/wiki/Hungarian_algorithm>; Kuhn (1955) <doi:10.1002/nav.3800020109>). This is a repackaging of code written by Cong Ma in the GitHub repo <https://github.com/mcximing/hungarian-algorithm-cpp>.

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cpp

7.24 score 6 stars 7 dependents 52 scripts 5.3k downloads

ALDEx3 - Linear Models for Sequence Count Data

Provides scalable generalized linear and mixed effects models tailored for sequence count data analysis (e.g., analysis of 16S or RNA-seq data). Uses Dirichlet-multinomial sampling to quantify uncertainty in relative abundance or relative expression conditioned on observed count data. Implements scale models as a generalization of normalizations which account for uncertainty in scale (e.g., total abundances) as described in Nixon et al. (2025) <doi:10.1186/s13059-025-03609-3> and McGovern et al. (2025) <doi:10.1101/2025.08.05.668734>.

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6.43 score 9 stars 27 scripts 224 downloads